Daily abdominal pain in the middle of the night is associated with irritable bowel syndrome, abdominal cold, and duodenal ulcer. Irritable bowel syndrome has more causes, such as improper diet and bad emotions. When irritable bowel syndrome attacks, the absorption of nutrients in the intestinal system will be affected and the intestinal function will be disrupted, which will lead to an attack in the middle of the night and therefore abdominal pain. You should try to keep your abdomen warm at night when you sleep. Once your abdomen gets cold, the organs of the abdominal digestive system will spasm and contract due to ischemia and lack of oxygen, thus causing pain. Most patients with duodenal ulcer will have hunger pain, especially pain at night as the main manifestation, which is mainly caused by excessive secretion of gastric acid in the middle of the night and the direct entry of gastric acid into the duodenum, causing violation of the duodenal mucosa.