Intermediate-differentiated squamous cell carcinoma originates from the squamous epithelium and is an atypical proliferation of the squamous epithelium in the early stage, and eventually becomes malignant as the disease evolves, and should be treated promptly after diagnosis, mainly by radical surgery. Because squamous cell carcinoma mainly occurs in the digestive tract and can also be found in the trachea, early and timely treatment is needed, and after surgery, adjuvant treatment options should be selected based on detailed pathological staging and immunohistochemical results. Because squamous carcinoma is a malignant tumor, it is relatively sensitive to radiation therapy and intravenous chemotherapy. Therefore, adjuvant therapy should be actively chosen after surgery, and the purpose of taking these treatment measures is to reduce the chance of recurrence after surgery, which can significantly improve the survival time of patients and, to a certain extent, reduce the pain of patients in the later stage.