Due to individual differences, there is no antihypertensive drug that minimizes the side effects of secondary hypertension, patients can choose diuretics, potassium-preserving diuretics, and α-blockers with β-blockers according to different causes for treatment. 1. Diuretics: Furosemide is commonly used clinically for hypertension caused by renal parenchymal lesions such as acute nephritis, chronic nephritis, diabetic nephropathy and chronic pyelonephritis. It may cause electrolyte disorders and affect the metabolism of blood lipid, blood sugar and uric acid. 2. Potassium-preserving diuretics: such as spironolactone can be used with surgery to treat hypertensive patients with adrenocortical hyperplasia. Side effects such as hyperkalemia and gastrointestinal reactions may occur after taking them. 3. α-blocker with β-blocker: such as phentolamine, metoprolol, etc. Combined application can be used for patients with hypertension caused by malignant pheochromocytoma. However, it may lead to side effects such as bradycardia, weakness, and dizziness in patients. Patients with secondary hypertension can go to the hospital under the guidance of the doctor to choose drugs reasonably, to avoid unauthorized medication on the body to cause adverse effects.