Refractory asthma has to be divided into several types. For most patients, refractory asthma is hormone-dependent/resistant asthma, which is manifested in: and poor response to hormone therapy, showing varying degrees of hormone resistance, requiring long-term dependence on high doses of inhaled hormones, or even oral hormones. The asthma that really does not respond to hormone therapy is not rare, and the reason for the uncontrollable condition mostly lies in the poor compliance of patients: this is one of the most important and common reasons for the difficulty in controlling asthma in China. This is the most important and common reason why asthma is difficult to control in China. The main reasons are: 1. not taking the medication according to the dosage and regimen of the written treatment plan; 2. not being able to evaluate and monitor their condition objectively and correctly; 3. not being able to use the medication inhalation device correctly; 4. not coming to the hospital regularly for follow-up; 5. using many so-called “prescriptions” that can “cure” asthma without authorization “There are also other conditions that cause asthma to fail. There are also other conditions that cause uncontrolled asthma, such as environmental factors, obesity, bacterial infections, and psychological factors. It is also important to note that there are some diseases that are misdiagnosed as asthma that are not effective when treated as asthma, such as gastroesophageal reflux, pulmonary cystic fibrosis, some endobronchial tuberculosis, and even lung cancer. As a patient, when facing “refractory asthma”, you need to pay attention to 1) consult a regular hospital to avoid misdiagnosis; 2) improve lung function, chest CT and other related examinations to correctly assess the severity of the disease; 3) use medication under the guidance of a doctor, and do not use or stop medication without authorization.