Fetus with duplication of chromosome 10 and deletion of chromosome 13 has obvious chromosomal abnormality and it is recommended to terminate the pregnancy as soon as possible. Normal fetus has 46 and 23 pairs of chromosomes, if there is chromosome 10 duplication of chromosome 13 deletion, it is a serious chromosomal abnormality, which will cause abnormal development of the fetus, mental retardation, organ deformities and other anomalies, and need to carry out amniocentesis to confirm this chromosomal abnormality of the fetus, and should terminate pregnancy as soon as possible after confirmation. Before the next pregnancy, both husband and wife should undergo chromosomal examination to check whether one of them has obvious chromosomal abnormality. If one of them does have chromosomal abnormality, they can choose IVF for chromosome screening of the embryo in order to get healthy embryo to help pregnancy.