Urine erythrocytes 4+ indicate the presence of hematuria. It may be due to urinary system diseases, systemic diseases, trauma, tumor, oral medication, other factors and so on. 1. Urinary system diseases: acute glomerulonephritis, urinary tract infection, urinary stones, nutcracker syndrome and other urinary system diseases may lead to hematuria. 2. Systemic diseases: epidemic hemorrhagic fever, aplastic anemia, purpura nephritis, systemic vasculitis may lead to hematuria. 3. Trauma: when the kidney is impacted by external force or suffers from severe vibration, it may cause mechanical injury and cause hematuria. 4. Tumor: Hematologic system tumors as well as a series of malignant tumors growing in kidney, ureter, bladder and urethra can cause hematuria. 5. Oral drugs: oral cyclophosphamide, heparin anticoagulants, adriamycin and other drugs may cause hematuria. 6. Other factors: In addition excessive exercise, insufficient water intake, nutritional deficiencies, etc. may also lead to hematuria. Urine erythrocytes 4 + may also have other reasons, it is recommended that the patient timely to the regular hospital, improve the examination to clarify the cause of the disease, under the guidance of the doctor to targeted treatment or treatment.