Hot and painful lips, this situation may be the lip area of herpes simplex, or herpes simplex has not yet occurred and the mucous membrane of the lip area of the pain symptoms, mainly due to infection with the herpes virus and the formation of the herpes. You can temporarily apply topical acyclovir ointment or spray acyclovir cream. At the same time, you can take appropriate oral antiviral drugs, you can take oral acyclovir tablets or vasiclovir tablets. Oral Chinese medicines can also be taken to clear heat and remove toxins, such as Niu Huang Shang Qing capsule or Gentian Diarrhea Liver Pill. This kind of fiery pain in the lips may also be caused by local trauma, especially traumatic injury, so, it is necessary to carry out debridement treatment at this time.