Vitamin B12 does not treat lumbar spondylolisthesis hyperplasia, but it can nourish the nerves and improve clinical symptoms. Vitamin B12, also known as cobalamin, is an essential water-soluble vitamin that is synthesized in the body. Life in a variety of foods are rich in vitamin B12, such as beef, pork, lamb, etc., as well as animal liver, kidney, etc., as well as fish and shrimp and other seafood, eggs and duck eggs. Bone spurs, also known as osteophytes, lumbar vertebral osteophytes is a degenerative lesion, hyperplasia of the bone will compress the lumbosacral nerves caused by varying degrees of lumbar and leg pain, vitamin B12 is indispensable to the sound functioning of the nervous system of the vitamins, involved in the formation of nerve tissues in the formation of a lipoprotein, with nutritional nerve function, to alleviate the lumbar pain has a certain degree of benefit. Patients with lumbar spondylolisthesis should pay attention to more rest, avoid sitting and standing for a long time, avoid bending, lifting heavy objects and other actions, nerve compression symptoms are serious should seek medical examination in a timely manner, according to the condition of the treatment, the use of drugs should be used under the guidance of a doctor to avoid adverse effects.