Diffuse large B-cell lymphoma in 80+ year olds can be considered for chemotherapy if the physical condition permits and there are no contraindications, so it is important that the patient undergoes a systemic evaluation. Diffuse large B-cell lymphoma belongs to the more common lymphoma in the clinic, and over 80 years old suffering from this disease, the patient’s general physical condition needs to be fully assessed. Chemotherapy should be aggressively chosen if it can be administered, as it is an important treatment modality for this disease. Chemotherapy, i.e. chemotherapy, the chemotherapeutic drugs used are cell-killing drugs which have the effect of killing cells. Since tumor cells are highly reproductive and grow very actively, chemotherapy drugs have a very strong killing effect on them. For patients who are in poor physical condition and are really unable to undergo chemotherapy, they can consider Chinese medicine to regulate their condition, so as to control the progression of their disease as far as possible and prolong their survival period.