The cost of a liver transplant and the duration of the procedure are related to the patient’s physical condition, the progression of the disease, and the hospital and region in which it is performed. The best time for liver transplantation is generally considered to be Child classification B. The cost is about 400,000 dollars on average. Patients with liver disease generally have a long and progressive disease course, and liver transplantation is the only effective treatment for end-stage liver disease. Due to the long duration of liver disease, tight liver supply and high risk of surgery, the cost of treatment is also relatively high, and together with the cost of follow-up treatment, the total cost is relatively higher. Some patients miss the best time for transplantation due to the high cost. In addition, the cost of liver transplantation varies due to different charging standards in different regions and hospitals. The average cost is generally around 400,000 yuan, and the cost will be even higher if there are infections and immune rejection during the recovery process after the operation. The choice of operation time for liver transplantation, due to the limited liver source, should choose the time entry point with less operation risk and less treatment cost. It has been studied that Child classification B is the best time to perform liver transplantation, which has relatively less surgical risk and less total treatment cost. Due to the tight liver source, patients with relatively stable condition in Child classification B can be operated at an elective stage, while patients with progressive condition in Child classification B should be prioritized for liver transplantation as soon as possible.