Lips licked up will be bitter may be mental bitter mouth, cholecystitis, gingivitis or periodontitis and other reasons. 1. Mental Bitterness: Especially for young people nowadays, the pressure of work and life is relatively high. Long-term mental tension can lead to irregular life and lack of sleep, which can lead to the phenomenon of licking up the lips will be bitter. 2. Cholecystitis: Because the liver and gallbladder function of patients with cholecystitis is poor, bile reflux may occur. When the bile refluxes into the stomach, the lips may become bitter when you lick them. 3. Gingivitis or periodontitis: After a night’s rest, patients with gingivitis or periodontitis may develop some bacteria inside their mouths, which may lead to the phenomenon of licking up bitter lips. If the phenomenon of patients licking up bitter lips for a long time can not be relieved, it is recommended to go to the hospital in a timely manner, follow the doctor’s instructions to receive treatment.