Most of the varicose veins lead to melanosis, which is difficult to be cured by medication; if the varicose veins develop further, the pigmented areas can easily lead to skin ulcers in the later stages. Melanosis caused by varicose veins is mainly due to the obstacle of local blood circulation after varicose veins, and the slow blood flow can easily lead to the formation of skin pigmentation. In the early stage of hyperpigmentation, blood activating drugs (such as Herbaceous rhinoceros infusion tablets, etc.) can be taken orally to improve the tortuous and dilated veins, thus improving the hyperpigmentation. For large areas of hyperpigmentation with a long course of the disease, it is difficult to recover from medication in most cases, and the hyperpigmentation can usually only be improved after surgical treatment. However, surgical treatment is usually not needed because the area has poor circulation, is slow to heal, and is prone to infection. If the varicose veins develop further, the late stage of hyperpigmentation is the stage of skin ulcers, such as the common late stage of hyperpigmentation with skin ulcers in the ankle area.