Acute sinusitis medication should be rationally selected under the guidance of the doctor, and the commonly used drugs are antibiotics, topical glucocorticosteroids, mucosal decongestants, antihistamines, mucus promoters and so on. 1. Antibiotics: antibiotics are the drugs of choice for patients with acute sinusitis, and you can choose penicillin antibiotics. Such as amoxicillin, piperacillin, if allergic to penicillin, you can also choose other kinds of antibiotics. Cell culture and drug sensitivity test should be performed before using antibiotics. 2. Glucocorticosteroids: commonly used glucocorticosteroids are budesonide and mometasone furoate, which mainly play a role in anti-inflammatory and anti-edema conditions. 3. Mucosal decongestants: commonly used nasal mucosal decongestants are hydroxymetazoline, ephedrine, etc., which can reduce nasal mucosal edema and promote drainage. 4. Antihistamines: some patients with acute sinusitis will be combined with allergic rhinitis, cetirizine, loratadine can be used to alleviate the sneezing and runny nose caused by allergic rhinitis. 5. Mucus promoter: patients with acute sinusitis may have difficulty in discharging secretions, you can choose mucus promoter such as eucalyptus-pinocampus to improve the situation. Patients with acute sinusitis should choose medicines under the guidance of doctors, do not blindly use medicines to avoid serious consequences.