Generally, Liu Wei Di Huang Wan can be taken together with Vitamin D, but the medication must follow the doctor’s instructions and pay attention to the contraindications of each. Liu Wei Di Huang Wan is a basic formula for tonifying kidney yin, composed of Poria, Ze Xie Di, Mudan Pi, Radix Rehmanniae Praeparata, Cornu Cervi Pantotrichum, and Chinese yam. Vitamin D is mainly used to prevent and treat vitamin D deficiency, such as rickets. Since no contraindications have been identified for these two medications, those who meet the indications can usually take them together as prescribed. The side effects of Liufidihuangwan are not known, and this drug should not be given to people with colds and fever or allergies to this drug, and should not be taken with cold medications. Prolonged overdose of vitamin D may result in dry and cracked lips, fever and headache, diarrhea, vomiting and other toxic phenomena. Patients with hypercalcemia, hyperphosphatemia with renal rickets, hypervitaminosis D, and allergy to the ingredients of this medicine are prohibited from using the medicine. In order to prevent improper use of medication from harming the body, patients must be instructed by a professional doctor when taking Liufidihuang Pill and vitamin D at the same time.