HP is the English surrogate for Helicobacter pylori, (-) would mean negative, the complete meaning is that the H. pylori infection is negative, meaning that the patient is not infected with H. pylori. Negative also has the possibility of false negative, for example, the patient did not stop acid suppressants, bismuth preparations and antibiotics at the time of the H. pylori test, this situation may cause a false negative, need to stop the medication preferably more than one month before the patient is re-examined, do a breath test test, if then negative, only then is said to be a true negative reaction. If the patient is in the process of acute gastrointestinal bleeding, or if the patient is a patient with a major gastrectomy, a breath test for H. pylori, even if negative, will not be a true reflection of H. pylori infection. This is because the accuracy of the breath test is reduced after a major gastrectomy, and the results of the breath test are not accurate during the acute phase of bleeding. Therefore, a negative H. pylori also requires a comprehensive analysis, as well as whether the reliability of the test means is true. Therefore, even if there is a negative H. pylori, it is important to communicate with the doctor to determine the reliable result of the negative test.