The worst result of the five tests for hepatitis B is the presence of positive hepatitis B surface antigen and positive hepatitis B E antigen, and the prerequisite for the presence of positive hepatitis B E antigen must be positive hepatitis B surface antigen. The reason is that a positive hepatitis B surface antigen indicates that the body has been infected with the hepatitis B virus, and the hepatitis B virus invades the body to replicate in large numbers in the body, and a positive hepatitis B E antigen is a sign that the hepatitis B virus is replicating in large numbers in the body, that is, if the hepatitis B E antigen is negative in the five hepatitis B items, it means that the hepatitis B virus is not replicating in the body.