Pain between the anus and the pubic area may be caused by perianal eczema, sebaceous cysts, warts and other factors, the patient should consult a doctor in time to clarify the cause of the disease. 1. Perianal eczema: a chronic recurrent inflammatory disease around the anus, lesions can also occur in the perineum, patients will have localized pain, itching, erythema, flaking, etc., such people should change underwear in a timely manner, the external use of zinc oxide paste for treatment. 2. Sebaceous cysts: If the patient has pain between the anus and the pubic area and there is localized protuberance and redness, it should be considered that the pain is caused by inflammation of sebaceous cysts, and the sebaceous cysts can be excised after the infection has passed. 3. Condyloma acuminatum: If the patient has had unclean sex before the pain between the anus and the pubic area, and there is a foreign body sensation, itching and small reddish or white particles, it should be considered to be caused by condyloma acuminatum, which can be treated with imiquimod, and surgically removed if necessary. The above medicines and treatments should be carried out under the guidance of a professional doctor.