Cracked lips do not heal for a long time if the lack of moisture is generally do not need to be treated, if it is caused by chronic lipitis and xerostomia, you can under the guidance of the doctor’s advice to apply local medicine to treat. 1. Lack of water: when a long time do not drink water or stay in a higher temperature environment, will make the body lose too much water, there will be cracked lips for a long time without healing symptoms, this situation is generally do not need to be treated, just need to supplement the water on time. 2. Chronic Lipitis: Chronic Lipitis may be caused by environmental factors, bad habits and bad habits, patients will have cracked lips and long time not healing phenomenon. Patients can apply Fosfomycin ointment locally for treatment. 3. Keratitis: Keratitis refers to the inflammation of the upper and lower lip joints, and the patient will have cracked lips that do not heal for a long time, and some of the patients are accompanied by blisters and scabs, etc. The patient can apply topical erythromycin to the lips to treat the problem. Patients can apply erythromycin ointment locally. The patient should be under the guidance of the doctor’s advice for the use of medication, do not remember to use, so as not to cause adverse effects, if you can not get relief also need to consult a doctor in a timely manner, to clarify the cause, under the guidance of the doctor’s treatment.