The treatment of esophageal cancer must pay attention to the psychological guidance of patients. Esophageal cancer patients often have depression, pessimism, despair and even suicidal tendency. Long-term severe anxiety and depression not only affect the patient’s quality of life, but also damage the immune function of the patient’s body and affect the patient’s anti-tumor ability. Therefore, in the process of esophageal cancer treatment, we must pay attention to the psychological guidance of patients. In the process of interaction with patients, nursing staff should influence patients’ perception and change their psychological state and behavior through good words, expressions, attitudes and behaviors, so as to make patients understand esophageal cancer correctly and cooperate with treatment with positive attitude. This is conducive to obtaining good treatment effect, improving patients’ quality of life and prolonging their lives. 2.After admission to the hospital and before surgery, we carry out scientific education about esophageal cancer, introducing the occurrence, development, treatment and influencing factors of esophageal cancer. Patients should have a correct understanding of esophageal cancer, build up confidence, relax training, face themselves and reduce their negative emotional reaction. 3.Psychological intervention: The heavy psychological pressure of esophageal cancer patients seriously affects the survival quality and physical and mental health of patients, and may accelerate the development of cancer. For the psychological state of esophageal cancer patients, effective psychological interventions should be carried out to improve patients’ adaptability to changes brought about by the disease, and to reduce or eliminate patients’ depression, anxiety and fear. Let the patients understand the general knowledge of the disease, introduce the surgery and the new technology and methods of treating esophageal cancer and successful cases of surgery, increase their confidence and courage to treat the disease and improve their adaptability to surgery. 4.Give sympathy, comfort and care to esophageal cancer patients in time, and establish mutual trust and equal patient-nurse relationship. We should contact and communicate with patients more before surgery, make more rounds and actively ask patients, understand patients’ needs in time and help solve them in time, so as to reduce patients’ communication barriers and eliminate patients’ pessimistic psychology, so that patients can spend the surgery period with the best state of mind.