Discontinuing and changing medication has a higher risk of causing fluctuations in the condition, so it should be approached with caution. Firstly, it is important to consider whether there are indications for stopping and changing medication, such as high side effects of the medication, the patient’s inability to tolerate the original medication, if the original medication is not effective, etc. Secondly, we should adopt the correct method of drug discontinuation and medication change to strive for a safe transition. There are several specific safe transition methods: 1. gradually increase the dose of the new drug while the original drug is being reduced. 2, first reduce the original drug, reduce to a certain dose and then combine the new drug, and then gradually reduce the original drug after the new drug is added to the full amount. 3. Combine the new drug first, add to a certain dose and then gradually reduce and stop the original drug.