The white knuckles may be caused by anemia, vitiligo and other reasons. 1. anemia: the body lacks trace elements, vitamins, etc., there may be malnutrition resulting in anemia, finger blood supply is insufficient so that the finger knuckle white symptoms, often accompanied by fatigue, fatigue, etc., generally do not need special treatment, usually should maintain a good diet, balanced nutrition, eat more vegetables and fruits. 2. Vitiligo: is a common acquired pigmentation loss of skin mucous membrane disease, may appear skin white symptoms, thus appearing knuckle white situation, can be used under the guidance of the doctor fluticasone propionate, mometasone furoate and other drugs for treatment. If long-term or recurring whitening of the knuckles of the fingers, patients should pay attention to, timely visit the hospital, follow the doctor’s instructions to standardize the treatment.