Alcohol should not be consumed for a week after taking toothache medication, and should not be consumed during any period of time when taking toothache medication. The medicines for toothache are generally categorized into antibiotics and painkillers, and it is not advisable to drink alcohol while taking these medicines. 1. Antibiotics: If there is periodontitis in the mouth and other infectious diseases will lead to toothache, need to use cephalosporin or nitroimidazole antibiotics to control the infection. When taking medication and drinking alcohol, disulfiram-like reaction will occur, facial flushing, chest tightness, nausea and dyspnea and other symptoms, and if you take too much, it will jeopardize life. Usually should not drink alcohol within a week of taking the drug. 2. Painkillers: Ibuprofen and other painkillers are usually used when you have pain in your mouth. Drinking alcohol while taking the medication may increase the toxic side effects of the medication. There will be some adverse reactions, causing gastrointestinal discomfort, and in serious cases, anaphylactic shock, alcohol poisoning, and damage to liver function may occur. To avoid adverse reactions, it is recommended to avoid drinking alcohol within one week of taking the medicine. Adverse reactions to alcohol consumption after taking the drug should be examined and treated in the hospital immediately.