Hair follicle shrinkage may be caused by physiological changes, seborrheic alopecia, baldness, etc. After clarifying the cause of the disease, it can be treated by general treatment, medication and surgery under the guidance of a doctor. 1. Physiological changes: As hair follicles are in the cycle of anagen, anagen and telogen effluvium, there will be physiological atrophy after a period of anagen, and when telogen effluvium occurs, it can re-enter the anagen phase to form a new follicular structure, usually no special treatment is needed. 2. Seborrheic alopecia: this disease is mainly caused by heredity, androgen, inflammation around hair follicles, stressful life, bad dietary habits, etc. It can be treated by medication under doctor’s guidance, common medications include finasteride, minoxidil, selenium sulphide lotion and other medications, and it can be treated by hair transplantation by transplanting hair follicles from the non-alopecia area to the alopecia area. 3. Patch baldness: when patients are affected by endocrine, genetic, autoimmune and other factors, it will lead to hair follicle atrophy, patients need to adjust the diet, supplement vitamins, proteins, and trace elements, but also through the local use of drugs, such as topical minoxidil or injection of glucocorticoids, etc. for treatment.