Protein (++++) is more serious, patients will have a large amount of urinary protein, which is commonly seen in glomerulonephritis-related diseases, and needs to be further combined with renal function, renal ultrasound and other items, as well as 24-hour urinary protein quantification and renal puncture biopsy to clarify the condition. Common causes include glomerulonephritis, nephrotic syndrome, diabetic nephropathy and so on. The treatment plan needs to be formulated according to the specific condition, and the commonly used drugs include ACEI or ARB, as well as hormones, immunosuppressants and so on. In the course of treatment, attention should be paid to regular follow-up and review to monitor changes in the condition. If the urinary protein is not controlled, it will continue to damage the kidneys, and even develop into kidney failure and uremia. In daily life, pay attention to not staying up late and overworking.