An elevated cortisol of 1000 mmol/L may be serious. Elevated cortisol can be seen in conditions such as hypercortisolism, adrenocortical tumors, partial pituitary tumors, and bilateral adrenocortical hyperplasia. Normal reference values for plasma cortisol are 137.95-634.57 mmol/L at 8 a.m. and 82.77-413.85 mmol/L at 4 p.m. Therefore, cortisol 1000 mmol/L is over the normal range. Due to different examination methods and reagents, the reference indexes are different in each hospital and need to be analyzed specifically. When abnormal cortisol values occur, it is recommended to go to the hospital and ask the professional doctor to make a comprehensive judgment in conjunction with your own situation, and it is not advisable to make a blind judgment on your own, so as to avoid delaying your condition and causing serious consequences.