As the saying goes, a journey of a thousand miles begins with the first step. Losing your feet means that you will have difficulty walking in your daily life. No one knows this better than patients who have had their feet amputated due to diabetes. Here, doctors want to remind everyone with diabetes to protect their feet as much as their eyes. The incidence of diabetic foot is about 2.8% to 14.5% in elderly diabetic patients. The main manifestations are pain in the lower limbs and skin ulcers. Amputations due to diabetic lower extremity vasculopathy are 5 to 10 times more common than in non-diabetic patients. Therefore, it is of great social importance to pay attention to the prevention and treatment of diabetic foot and actively save the limbs. The early symptoms of diabetic foot are mainly itching of the skin of both feet, coldness, numbness and dullness of sensation. The symptoms of local ischemia of the lower limbs are mainly vascular intermittent claudication, which is characterized by the following manifestations. Symptoms appear only when walking and disappear rapidly (usually within 5 minutes) after stopping walking, and the same symptoms appear with the same walking. Further changes in the disease may result in resting pain, i.e., pain in the lower limbs even at rest, and even sleeplessness through the night. At the end of the disease process, ulceration and necrosis form on the foot, and the wound does not heal for a long time. The above disease is mainly caused by the disorder of sugar, fat and protein metabolism in diabetic patients, the thickening of the intima and the accelerated process of calcification of the intima, and this degenerative change is about 10-15 years earlier than normal people, resulting in a decrease in vascular dilatation capacity. Normally, clinical ischemic symptoms are present only when the vessel is narrowed to 3/4 of its diameter. During this rather long period of time, the patient himself usually does not care very much, and by the time the symptoms worsen it is already advanced, the foot is necrotic and gangrenous, and general treatment is hardly effective, and the patient will have to undergo amputation in order to save his life. Therefore, early detection and treatment is very important. Diabetic patients are prone to peripheral neuritis, the patient’s sensitivity to pain is low, prone to injury, and even a small wound may lead to difficult to heal ulcers, so diabetic patients usually pay attention to foot care. Check the feet daily for blisters, redness and swelling and broken skin; wash the feet daily to keep the toes dry and prevent mold infection; apply emollients such as petroleum jelly daily to prevent dry and cracked feet; do not use hot water bags or electric blankets for warmth; do not cut calluses and corns, trim toenails not too short, and do not walk barefoot to avoid injury. The main purpose of diabetic foot medication is to improve circulation in the lower limbs. Commonly used drugs include enteric aspirin, compound danshen tablets and reserpine to reduce blood viscosity and platelet aggregation; pepeda, pancreatic kinase releasing enzyme and hexoketone cocaine to dilate blood vessels and improve microcirculation. In addition, smoking should be stopped to maintain the therapeutic effect. The surgical treatment of diabetic foot includes angioplasty and arterial reconstruction, in addition to insistent wound dressing change. Arterial reconstruction is to restore blood flow to the ischemic tissues of the distal limb through the bypass of the ischemic segment by means of autologous or artificial blood vessels, which is commonly known as “bypass” surgery. Angioplasty is a minimally invasive intervention that involves inserting a balloon catheter to dilate the stenotic vessel and reshape the intima to increase blood flow and improve the distal blood supply. In particular, the small and long balloon technique recently carried out in our hospital has enabled good recanalization of narrowed vessels in the lower leg, which were originally thought to be off-limits, and has greatly saved the diseased limbs of diabetic foot. Angioplasty has the advantages of being minimally invasive, non-incisional (if there is an incision, it is the eye of a needle), minimally invasive, and fast recovery. In recent years, it is being widely carried out and is becoming more and more perfect, which is undoubtedly a blessing for diabetic patients. If the patient’s vascular disease is more serious, it is no longer possible to perform angioplasty or reconstruction, and the final fate can only be amputation. Diabetic patients are often combined with hypertension and hyperlipidemia, so control blood pressure and blood lipids, and obese patients should lose weight properly. In addition, should also be appropriate exercise.