Subcutaneous lipoma pain may be caused by excessive compression, local injury, infection and other factors. 1. Excessive compression: after the size of subcutaneous lipoma increases, it may cause compression to the surrounding surface nerves or pull the skin, which will cause pain symptoms. 2. Local injury: after subcutaneous lipoma is not taken care of, the external force strikes or excessive pressure, which makes the subcutaneous lipoma locally broken, and then it will cause pain symptoms. 3. Infection: when subcutaneous lipoma has localized rupture, it may lead to bacterial infection, which will cause pain after serious infection, and may be accompanied by oozing, redness and swelling and other symptoms. The pain of subcutaneous lipoma indicates the existence of abnormal conditions, and it is recommended to consult a doctor for corresponding examination and surgical treatment to avoid causing other complications.