Levofloxacin is not a substitute for pyrazinamide. Levofloxacin and pyrazinamide are two completely different drugs. Levofloxacin is a quinolone antimicrobial drug, which is mainly used for the treatment of infectious diseases caused by sensitive gram-negative and gram-positive bacteria, whereas pyrazinamide is an anti-tuberculosis drug, which is mainly used for the treatment of tuberculosis diseases, so Levofloxacin cannot replace pyrazinamide. Pyrazinamide can be replaced by other anti-tuberculosis drugs, such as ethambutol and streptomycin, if resistance or other adverse reactions occur during treatment. In the anti-tuberculosis drug treatment, must be instructed by the doctor to use the drug, the patient should not use the drug at will, especially can not be arbitrarily stopped to reduce the drug, if the drug appeared to have an adverse reaction, must be instructed by the doctor to replace the other drugs. If you are allergic to the ingredients of these two drugs, you are forbidden to take them, and if you experience serious adverse reactions, such as nausea, diarrhea, vomiting, etc., you need to stop taking the drugs and go to the doctor in a timely manner.