The location of knee pain is disease related and is more common in the medial-lateral compartment of the knee, and to a lesser extent pain can also be present in the posterior patella and the posterior aspect of the knee. There are more causes of knee pain, such as knee fracture, meniscus injury, knee osteoarthritis, knee ligament injury, patellar dislocation, popliteal cyst and so on. 1. Medial knee joint pain: when the knee joint medial tibial or femoral condyle fracture, knee joint medial collateral ligament injury or rupture, medial meniscus injury, as well as medial knee osteoarthritis, etc., can lead to the medial knee joint pain, and most of the pain is significant in the activities. 2. Lateral knee gap pain: when the lateral tibial or femoral condylar fracture, lateral collateral ligament injury, lateral meniscus injury, and lateral knee osteoarthritis, etc., can cause lateral knee pain, which is also significant during activities. 3. Posterior patellar pain: if chondromalacia patella, patellar dislocation, patellar fracture and patellofemoral arthritis occurs, it can be manifested as posterior patellar pain, which can be relieved when resting. 4. Posterior knee joint: such as osteoarthritis of the knee joint, posterior meniscus angle tear or posterior cruciate ligament injury, as well as popliteal cyst, etc., can lead to pain at the posterior side of the knee joint. Apparent pain in the knee joint occurs, and the location of the pain varies from disease to disease, so it is necessary to actively consult the doctor and follow the doctor’s instructions for reasonable treatment.