Insomnia once taking methylprednisolone is mainly considered to be related to adverse drug reactions. The possibility of somatic, environmental, and psychological factors should also be considered. 1. Adverse reactions: according to the drug specification, the adverse reactions of this drug include mental abnormalities, such as insomnia, anxiety, mental disorders, mood swings and so on. 2. Physical factors: such as too much fatigue or the original disease has not been effectively controlled, can be triggered by insomnia after using the drug. 3. Environmental factors: the bedroom light is too strong, the temperature is too high, or the surrounding sound is noisy and other factors, can also trigger insomnia. 4. Psychological factors: during the period of taking medication, there is tension, fear, anxiety and other adverse emotions, may also trigger insomnia. Insomnia after the use of drugs, the reasons are more complex. It is recommended to consult a doctor as soon as possible to confirm the cause of the disease, to be targeted treatment. Drugs should be used under the guidance of a doctor.