Ibuprofen can relieve toothache due to its antipyretic and analgesic effects, but it can only provide symptomatic relief and cannot cure the primary disease causing the toothache. 1. Ibuprofen is an antipyretic and analgesic, non-steroidal anti-inflammatory drug, which can be used to relieve mild to moderate pains such as toothache, headache, arthralgia, migraine, muscular pain, neuralgia, menstrual cramps and so on. Therefore, if the toothache is unbearable, ibuprofen can be used as appropriate to relieve, but for pain relief should not be used for more than 5 days, and should not be used for a long time or a large amount. 2. It should be noted that taking ibuprofen may cause stomach upset, abdominal pain, nausea, vomiting, rash, itching, facial edema and other adverse reactions, pregnant women and breastfeeding women are prohibited, suffering from severe liver disease, renal disease, peptic ulcers, blood abnormalities and other people should also be prohibited. Toothache is mostly caused by gingivitis, periodontitis, dental caries, etc., which leads to pulpal infection. For recurrent toothache, it is recommended to go to the dentist as soon as possible and undergo standardized and comprehensive treatment in order to avoid recurrence of the condition.