A map-like bone defect is one of the symptoms of Hand-Schüller-Christian disease. Hand-Schüller-Christian disease, also known as subacute or chronic differentiated histiocytosis, used to be called Han-Schüler-Coeur disease, which is different from Letterer-Siwe disease and eosinophilic granuloma of bone. granuloma of bone) are different manifestations of histiocytosis (Langerhans cell histiocytosis) because they share common histopathological features, except that the age of onset is different, the clinical manifestations are different, there are acute and subacute differences, and the prognosis is also different. So how is the diagnosis made clinically? The diagnosis is not difficult in patients presenting with the typical triad of uveitis, proptosis and geographic bone defects. In atypical lesions laboratory tests should be performed and combined with imaging findings to determine the diagnosis.