Taking isotretinoin to appear dry skin is likely to be its adverse reaction, need to promptly go to the medical consultation, under the guidance of a professional doctor to reduce or stop the drug, change the drug. Isotretinoin can reduce the secretion of sebaceous glands and inhibit the growth and reproduction of Propionibacterium acnes, and is commonly used in the treatment of severe refractory nodular acne. Most adverse reactions to isotretinoin include drying of the skin mucous membranes, thus requiring a reduction in dosage or discontinuation or change of medication when dryness of the skin occurs. Other adverse reactions include allergic reactions, edema, fatigue, and palpitations. To avoid the occurrence of adverse reactions, patients need to take Isotretinoin under the guidance of a medical professional, and it is contraindicated in people who are allergic to Isotretinoin, pregnant and lactating women, people with liver and kidney insufficiency, and people with vitamin A overdose. The drug needs to be used under the supervision of a doctor.