There is no fastest way to sober up, you can usually sober up by medication, drinking more water and resting properly. 1. Medication: After drinking, you can take hydrochlorothiazide tablets or compound furosemide tablets as prescribed by the doctor to promote urination, so that alcohol is excreted through glomerular filtration, or you can go to the hospital to inject naloxone hydrochloride injection, so as to achieve the effect of sobriety. 2. Drink more water: drink more water after drinking, can dilute the concentration of alcohol in the blood, and at the same time promote the excretion of alcohol, so as to achieve the effect of sobriety. 3. Appropriate rest: appropriate rest helps the body metabolize, can promote better metabolism of alcohol, so as to achieve the effect of sobriety. If you can’t get relief from resting and drinking water, we suggest that you consult a doctor to get relief through medication. The above medication should be used in accordance with the doctor’s instructions.