Nodular goiter has a certain chance of becoming cancerous, which is around 5%. Simple goiter, if repeated hyperplasia and recurrence, some nodules may develop atypical hyperplasia or even carcinoma, but the chance is low. Through ultrasound examination, we can initially determine whether the nodules are cancerous or not, and clinically, we can mainly look at the nodule size, morphology, degree of close adhesion with the surrounding tissues, and internal structure, etc. If malignant changes are suspected, we should intervene as early as possible, and pathological biopsy can be used to make a clear diagnosis. For nodular goiter, there is generally no need to worry too much, regular review, usually 3~6 months ultrasound examination of the shape of the nodule, if malignant changes should be determined in time for surgery, to ensure that the patient’s maximum survival time.