Macrolides are a class of antibiotics that have macrolides in their chemical structure. The chemical structure of macrolide antibiotics has a 14 to 16 carbon lactone ring. Macrolide antibiotics are mainly used to treat gram-positive and negative cocci, and a few anaerobic bacteria. Common macrolide antibiotics include azithromycin, clarithromycin, erythromycin, and roxithromycin. Their mechanism of action is to inhibit the protein synthesis of bacteria and may inhibit bacterial activity. As an antibiotic drug, macrolides need to strictly follow the doctor’s instructions for standardized medication, and avoid smoking and alcohol, to avoid affecting the efficacy of the drug. In addition, we should pay attention to the existence of allergic reactions, nausea, vomiting, diarrhea and other adverse reactions during the drug, for allergy, liver function impairment and lactating women are contraindicated.