Pre-conception and pregnancy care are important measures to reduce the incidence of complications and mortality of pregnant women and perinatal babies, and to reduce birth defects. To ensure the superiority of the baby, preconception screening is essential. Preconception care is a forward movement of pregnancy care by assessing and improving the health status of the couple planning pregnancy and reducing or eliminating risk factors that lead to adverse pregnancy outcomes such as birth defects, thereby preventing the occurrence of birth defects. At this stage, pregnancy checkups are generally recognized and many expectant fathers and mothers ignore the preconception checkups, what do you need to pay attention to during preconception checkups? 1, reasonable nutrition, avoid overweight, planned and prepared pregnancy; 2, the couple has not done marriage test, or had a history of stillbirth, stillbirth, mental retardation, habitual abortion, need to go to the regular hospital pre-conception medical examination; 3, the couple has chronic diseases, genetic diseases and infectious diseases of women who are ready to pregnancy, in the regular hospital to assess and give corrective guidance; 4, reasonable supplementation of folic acid 0.4-0.8 4. Pregnant women who have given birth to a child with neural tube defects should increase the daily folic acid supplement to 4mg per day. 5. For those who have not undergone gynecological examination within 1 year, gynecological ultrasound and cervical cytology should be performed to exclude cervical lesions; 6. Use medication reasonably, avoid exposure to harmful substances in life, change bad habits, maintain psychological health and be ready to welcome new life. 7, maintain a good state of mind, avoid drinking and smoking, make good psychological preparation before pregnancy, at the same time, you should not be too anxious, let nature take its course, you can test ovulation properly, but there is no need to be eager. Ensure that the mind, let nature take its course is the best.