Red skin marks may be caused by urticaria, allergy, lupus erythematosus, etc. They can be eliminated quickly by topical or oral medication. 1. Urticaria: Mast cell activation will lead to edematous lumps on the skin surface, which can be treated with oral antihistamine drugs, such as cetirizine, loratadine and so on. 2. Allergy: skin contact with allergens will occur metamorphosis, causing skin red marks, you can apply hydrocortisone cream, etc. If the red marks are large, accompanied by burning sensation, itching, etc., you can take oral antihistamines, such as ibastine, loratadine, etc.. 3. Lupus erythematosus: this is an autoimmune disease, there will be skin symptoms, such as erythema pteronyssinus, acute exacerbation of the symptoms of the milder, can be applied mometasone furoate ointment, tacrolimus ointment, pimecrolimus ointment, vinpocetine, tazarotene and so on. Oral hydroxychloroquine and methotrexate may be taken for those that are not effective. All of the above drugs may produce adverse reactions, so the use of medication need to be guided by a doctor, avoid self-medication. It is recommended that patients consult a doctor in time and standardize the treatment under the doctor’s guidance.