Rounded low-density shadow is seen in the right lobe of the liver with a size of 3.3 centimeters, considering benign lesion or malignant lesion, which cannot be treated by oral medication. 1. Benign lesion: round slightly low density shadow in the right lobe of the liver is caused by liver lesion with lower density than normal liver tissue, which can be shown in CT or MRI test, and the nature of the density shadow of the liver is initially judged according to whether the edge is clear or not, whether the internal echo is regular or not, and whether the density is uniform or not. Benign lesions are considered to have hemangiomas, cysts and other problems, and the nature of the low density shadow cannot be determined solely by virtue of the low density shadow, which can be diagnosed by combining with clinical MRI, alpha-fetoprotein, liver puncture and so on. Liver puncture for biopsy has certain risks, and puncture is strictly prohibited when hepatic hemangioma is suspected or cannot be excluded. 2. Malignant lesions: the discovery of hypodense shadows should also exclude the presence of malignant tumors of the liver, assess the blood supply of the mass, and combine with the value of alpha-fetoprotein to make a preliminary judgment. If you find low-density foci in the liver, go to a regular hospital, get a clear diagnosis first, and under the guidance of a physician, give targeted treatment according to the cause, and don’t blindly use drugs by yourself.