Endometrial cancer with POLE mutation can be treated by medication and surgery. 1. Drug treatment: patients with POLE mutation endometrial cancer can take oral progesterone tablets, medroxyprogesterone tablets and other progestational hormones as prescribed by doctors, and can also use carboplatin, paclitaxel, doxorubicin and other chemotherapeutic drugs. In addition, patients can also use targeted therapy drugs such as Sunitinib malate capsules and Sorafenib tosylate tablets as prescribed by doctors. 2. Surgical treatment: patients with POLE mutant endometrial cancer can also adopt surgical treatment, mainly adopting surgical methods such as total uterine bilateral salpingo-oophorectomy, unaccompanied pelvic and para-abdominal lymph node dissection. It is suggested that patients with POLE mutant endometrial cancer should ensure sufficient rest in daily life, avoid staying up all night and exertion. Patients should eat less spicy and stimulating food, such as chili peppers and ginger. Patients with POLE mutant endometrial cancer should consult doctor in time and take treatment under doctor’s guidance to avoid aggravating the condition.