Patients with Parkinson’s disease often have a combination of hypotension, manifested as dizziness on rising, which is generally a manifestation of long-term use of dopa preparations, receptor agonists, do not consider the patient is not primary Parkinson’s disease or have other diseases once postural hypotension is found. If a patient has postural hypotension early in the course of the disease, and at this time, he or she often has not applied the compound dopa preparation, and the clinical efficacy after applying the dopa preparation is not significant, it is best to examine the pontine brain with cross signs on MRI, then multi-system atrophy should be considered. This determination is important because primary Parkinson’s disease can also be treated with the option of deep electrical stimulation, whereas multisystem atrophy cannot. Treatment is consistent. Increasing salt intake, changing position more slowly, wearing elastic bandages, etc., and medications are applied to tubotone, which is a peripheral vascular alpha1 receptor agonist that is effective in improving postural hypotension. The dose is 2.5 mg per tablet, starting with half a tablet each time, twice a day, which can be increased to 6 tablets per day. However, not every patient is suitable to take the medication, and the medication has side effects. One of my patients I was trying to apply prednisone, another patient tried to adjust to take another antihypertensive drug, and the 80-year-old patient discontinued the levodopa preparation and observed the effect with the receptor agonist alone.