The generic name for Heartgard is propranolol. It can usually be taken at the same time as digoxin and has anti-heart failure effects. Propranolol is a beta-blocker commonly used in the clinic, which has the effect of anti-heart failure, anti-arrhythmia, and reducing sympathetic excitability. It is generally contraindicated in atrioventricular block, bradycardia, bronchial asthma, and peripheral vasospastic disease. Adverse effects are sinus bradycardia, depression, fatigue, hypotension, etc. Digoxin belongs to the cardiac glycoside class of drugs, which has the effect of increasing myocardial contractility and antiarrhythmia. Contraindications are cardiac glycoside toxicity, ventricular fibrillation, and preexcitation syndrome. Adverse reactions are arrhythmia, gastrointestinal reactions, jaundice, diarrhea and so on. Clinically, patients with heart failure can apply both propranolol and digoxin to achieve the effect of anti-heart failure. However, it should be noted that the two lead to atrioventricular block causing severe bradycardia, and heart rate monitoring is required for co-use. In addition, the safety range of digoxin is small, individual variation is large, and the symptoms of toxicity are similar to those of heart failure, so it is easy to be confused. Therefore, it must be used strictly according to medical advice to avoid adverse reactions.