Lymphoma is a malignant neoplastic disease that originates in the lymph nodes and lymphatic tissue. In general, there are no specific clinical manifestations of lymphoma blood work. Occasionally, in patients with Hodgkin’s lymphoma, blood work may show mild or moderate anemia. In non-Hodgkin’s lymphoma, white blood cells are sometimes elevated, mainly as a lymphocyte count, or in absolute terms. When the advanced stage of lymphoma infiltrates the blood or bone marrow, there are significant changes in the blood count, with most white blood cells elevated and sometimes normal or decreased. However, the hemoglobin or platelets are often significantly reduced, with corresponding clinical symptoms, such as easy infection, fever, or generalized weakness and other anemia symptoms, as well as clinical manifestations such as bleeding from the skin and mucous membranes.