The numbness of right big toe may be caused by cerebral infarction, usually seen in lacunar cerebral infarction or radiocoronal cerebral infarction, most patients with small infarction foci mostly seen on the left side of the lesion, the patient may also have speech dysfunction, including aphasia and dysarthria, and may also appear in the right side of the limb motor dysfunction. Oral vitamin B12 and methylcobalamin can be used for neurological treatment, and active treatment of cerebral infarction should be provided, including antiplatelet aggregation therapy, neuroprotective therapy, and improvement of blood circulation therapy, and active control of the cause of the disease. It may also be caused by lumbar spine lesions, lumbar spine lesions mainly include lumbar disc herniation, lumbar curvature straightening and lumbar vertebral osteophytes, which may compress the lumbar spinal cord in severe cases, and the patients may have numbness of toes or both lower limbs, and some patients may have abnormal urination and defecation, etc. The main treatment is to carry out massage therapy of lumbar muscles, traction therapy, and surgery can be considered when necessary.