Fibromatosis multiforme generally refers to multiple neurofibromas, which are mainly related to genetics and can be triggered by hormonal fluctuations or disease factors. Multiple neurofibromas refer to multiple fibrous nodules or fibrous hyperplasia lesions on the skin and internal organs, which need to be cleaned and sanitized during the disease, avoid scratching and rubbing the skin to prevent skin damage and infection. 1. Genetic causes: Multiple neurofibromas are autosomal dominant, due to genetic defects, so they have a great relationship with heredity, and the mutated genes are mainly NF gene; 2, hormonal fluctuations: puberty, pregnancy, lactation are more likely to appear multiple neurofibromas, suggesting that hormones and the disease have a certain relationship; 3, disease factors: alcoholism, diabetes, etc. can induce multiple neurofibromas, but the mechanism is unknown. Multiple neurofibromas can cause skin pigmentation, usually with milk coffee spots, and can also lead to diffuse masses of different sizes all over the body, which can affect the aesthetics of the skin. In severe cases, the disease can also lead to compression of nerves or internal organs, such as mental retardation, memory impairment, seizures, and low back pain. Therefore, surgical excision is required if necessary. If there are only pigmented spots and subcutaneous nodules, the growth rate can be temporarily observed without special treatment.