Chromosome mk stands for monosomal-karyotype (MK) and is the result of cytogenetic analysis. Monosomal-karyotype is the presence of 2 or more autosomal monosomes or 1 autosomal monosome alone as a result of cytogenetic analysis. However, at least 1 additional structural abnormality is present at the same time, subject to exclusion of t(15; 17), t(8; 21), and inv/t(16) AML-RGA; highly abnormal CK is associated with 5 or more unrelated chromosomal abnormalities. Monosomal karyotypes are of prognostic importance in acute leukemia, and the presence of a monosomal karyotype chromosome regardless of the number of chromosomes involved often suggests a poor prognosis. In the clinic, when cytogenetic detection of chromosomal monokaryotype, should promptly go to the regular hospital, and under the guidance of the doctor for treatment.