The right side of the abdomen in mid-pregnancy pain caused by physiological causes do not need treatment, pathological causes caused by a clear cause, such as preeclampsia need medication to protect the fetus treatment. 1. Physiological reasons: mid-pregnancy is with the increase of the uterus, will pull the surrounding ligaments and may cause the right side of the abdomen pain, this is a normal physiological phenomenon, the pain is intermittent, no other symptoms, do not need special treatment. 2. Pathological causes: (1) preeclampsia: can also cause the right side of the lower abdomen pain, can also be accompanied by a small amount of vaginal bleeding, ultrasound fetal development is good, cervical canal shortening, need to follow the doctor’s advice to rest, and give progesterone, nifedipine and other drugs to protect the fetus treatment. (2) Appendicitis: it can also cause vague pain in the right side of the abdomen, and can be accompanied by pressure and rebound pain in the right lower abdomen. The combination of clinical manifestations, ultrasonography, or routine blood tests can assist in the diagnosis. Antibiotic treatment, such as metronidazole, penicillin, etc., needs to be given as prescribed by the doctor, and surgical treatment is needed if necessary. (3) right ovarian cyst tip torsion: affected by the enlarged uterus, it can manifest as persistent right lower abdominal hidden pain, section through ultrasonography, gynecological examination, etc. to assist in the diagnosis, and need emergency surgical treatment. When the right side of the abdomen hidden pain in mid-pregnancy need to go to the hospital in a timely manner, in order to identify the cause, and actively deal with. In addition, the specific use of the above drugs needs to be under the guidance of a doctor.