High partial thromboplastin time is common in patients with various coagulation factor deficiencies, as well as in patients who have applied heparin. After the occurrence of high partial prothrombin time, the following methods are commonly used: i. Plasma supplementation therapy, as plasma contains various coagulation factors, by supplementing plasma, the concentration of coagulation factors in blood can be increased, thus correcting the high partial prothrombin time; ii. Cold precipitation supplementation therapy, cold precipitation is concentrated plasma, the concentration of various coagulation factors is higher, by supplementing cold precipitation can The high partial prothrombin time can be corrected by supplementing cold precipitation; third, supplemental vitamin K treatment, vitamin K can synthesize partial coagulation factors, thus improving the high partial prothrombin time; fourth, if the high partial prothrombin time is caused by the application of heparin, fish essence protein can be applied to neutralize the heparin in the blood, thus reducing the high partial prothrombin time.