Adapalene Gel can be used together with Fusidic Acid Cream, mainly used for the treatment of acne, during the application process should first use Adapalene Gel, half an hour interval and then use Fusidic Acid Cream. Acne is a chronic inflammatory skin disease, mainly manifested as pimples, papules and pustules on the facial skin, and is mainly treated with anti-inflammatory and keratolytic drugs. The main ingredient of adapalene gel is adapalene, which belongs to a kind of retinoid compound, the drug has anti-inflammatory properties, but also has the effect of dissolving pimples, thus reducing the symptoms of acne. The most common adverse reactions during use are localized erythema, dryness, itching and flaking of the skin. Fusidic acid cream, the main ingredient of which is fusidic acid, is a kind of topical antibiotic, which is often used for the treatment of various bacterial infectious skin diseases, including acne. Adverse effects of the drug mainly include local itching, erythema and so on. From the available clinical data, fusidic acid cream combined with adapalene gel for the treatment of acne vulgaris is more effective than treatment with one drug alone. In order to ensure the safety and effectiveness of the medication, it is important to use it in strict accordance with the doctor’s instructions.