Pre-menopausal menstruation has been non-stop, may be related to the body’s hormone level instability and other physiological factors, is a normal phenomenon; may also be some organic diseases, such as endometrial cancer, endometrial polyps and so on. 1. Physiological factors: For patients who have unstable hormone levels that lead to non-stop menstruation before menopause, it is recommended to develop good living habits, drink more hot water, achieve emotional stability and improve immunity through appropriate exercise; or follow the doctor’s instructions to use estrogen and progesterone, such as estradiol valerate and progesterone. 2. Pathological factors: (1) Endometrial cancer: the main symptoms of endometrial cancer are vaginal bleeding, discharge of fluid, abdominal pain and abdominal mass. If endometrial cancer is diagnosed, surgery is the main treatment means. For endometrial cancer of various stages accompanied with serious medical complications, advanced age and other conditions that are not suitable for surgery, radiation therapy and drug therapy can be used. (2) Endometrial polyps: endometrial polyps are usually inflammatory polyps caused by a combination of factors such as infection and irritation, and usually require combined treatment of drugs and surgery. Drug treatment is mainly anti-inflammatory treatment, commonly used drugs are non-steroidal anti-inflammatory drugs, such as aspirin, ibuprofen, aminopyrine and so on. Surgery is mainly performed through hysteroscopy for polypectomy, and endometrial curettage is often required for patients with multiple polyps. The menstruation has been non-stop menstruation, if it lasts for a long time, it is recommended to go to the hospital in time, under the guidance of the doctor to identify the cause of the disease, and actively cooperate with the treatment.